United States

The Global State of Genome Editing

This project applies automated literature mining of scientific publications on genome editing in to infer research trends in the development of genome editing technologies especially CRISPR/Cas systems and TALENs.

Research Focus

  • Computational Science

    Computational science is a multidisciplinary field that utilizes advanced computing to understand and solve complex problems. Researchers at the EIGH develop computational models, hardware, software, data management, and more to tackle a variety of global health concerns.

  • Genetics and Genomics

    One way to study certain diseases is through genetics - the study of heredity and the variation of individual inherited genes in an organism. At the EIGH, this means studying how organisms can inherit and spread certain diseases. Additionally, by analyzing the entire structure, function, and evolution of an organism's genes, researchers may identify ways to prevent a disease from genetically passing disease traits.

  • Molecular Biology and Microbiology

    Researchers at the EIGH use microbiology, which encompasses the study of an entire microorganism, and molecular biology, or the interactivity between molecules within a cell of an organism, to better understand disease and improve global health. 

Who’s Involved

EIGH Faculty

Global Partners

  • University of Arizona

Notre Dame Partnerships

  • Center for Research Computing


Additional Information


Siwo G.H. (2018). The Global State of Genome Editing. bioRxiv 341198; doi: https://doi.org/10.1101/341198

Media Coverage

Interview on the BioTechniques magazine podcast “CRISPR: developing an equitable technology amidst a global pandemic”- https://shows.acast.com/talking- techniques/episodes/crispr-developing-an-equitable-technology-during-a-global-pa

Contribution of global CRISPR research data to Science Magazine series of articles on “China’s CRISPR Revolution”- https://www.sciencemag.org/news/2019/08/its-crispr-revolution-china-becomes-world-leader-genome-editing

Interview on TED Fellows blog on “Let’s design CRISPR to benefit everyone while we still can”- https://fellowsblog.ted.com/lets-design-crispr-to-benefit-everyone-while-we-still-can-414b6c30aed9

Genetic Literacy Project coverage- “Who will CRISPR benefit? How to prevent this life-saving technology from creating gender and geographical disparities” - https://geneticliteracyproject.org/2018/07/10/who-will-crispr-benefit-how-to-prevent-this-life-saving-technology-from-creating-gender-and-geographical-disparities/




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