The Global State of Genome Editing
This project applies automated literature mining of scientific publications on genome editing in to infer research trends in the development of genome editing technologies especially CRISPR/Cas systems and TALENs.
Computational science is a multidisciplinary field that utilizes advanced computing to understand and solve complex problems. Researchers at the EIGH develop computational models, hardware, software, data management, and more to tackle a variety of global health concerns.
Genetics and Genomics
One way to study certain diseases is through genetics - the study of heredity and the variation of individual inherited genes in an organism. At the EIGH, this means studying how organisms can inherit and spread certain diseases. Additionally, by analyzing the entire structure, function, and evolution of an organism's genes, researchers may identify ways to prevent a disease from genetically passing disease traits.
Molecular Biology and Microbiology
Researchers at the EIGH use microbiology, which encompasses the study of an entire microorganism, and molecular biology, or the interactivity between molecules within a cell of an organism, to better understand disease and improve global health.
- University of Arizona
Notre Dame Partnerships
- Center for Research Computing
Siwo G.H. (2018). The Global State of Genome Editing. bioRxiv 341198; doi: https://doi.org/10.1101/341198
Interview on the BioTechniques magazine podcast “CRISPR: developing an equitable technology amidst a global pandemic”- https://shows.acast.com/talking- techniques/episodes/crispr-developing-an-equitable-technology-during-a-global-pa
Contribution of global CRISPR research data to Science Magazine series of articles on “China’s CRISPR Revolution”- https://www.sciencemag.org/news/2019/08/its-crispr-revolution-china-becomes-world-leader-genome-editing
Interview on TED Fellows blog on “Let’s design CRISPR to benefit everyone while we still can”- https://fellowsblog.ted.com/lets-design-crispr-to-benefit-everyone-while-we-still-can-414b6c30aed9
Genetic Literacy Project coverage- “Who will CRISPR benefit? How to prevent this life-saving technology from creating gender and geographical disparities” - https://geneticliteracyproject.org/2018/07/10/who-will-crispr-benefit-how-to-prevent-this-life-saving-technology-from-creating-gender-and-geographical-disparities/
Other Research in United States
- Lead poisoning prevention initiative
- Sand fly genome project
- Role of Doulas in Health Disparities
- Rapid and Multi-Target Virus Isolation, Detection and Quantification for Point-of-Care Applications
- Investigating Patient Cognitive Load and Stress Levels During Postpartum Discharge
- Postpartum Complications: Women’s Knowledge and Impact of Post-Birth Discharge Education
- Improving Human Papilloma Virus-Vaccination Rates
- Vaccine Mapper
- Insecticide discovery
- Deciphering the mosquito's visual capabilities
- The cell biology and pathogenesis of cryptococcal disease
- Community-based participatory research with AIDS Ministries/AIDS Assist
- Bacterial Pathogenicity in Catheter-Associated Infections
- Developing Genomic Tools for Combating Chagas Disease
- Effect of COVID-19 on exercise routines