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Bacterial Cell Wall, Its Biosynthesis and Recycling and Its Nexus to Antibiotic Resistance

 

Research focuses on the bacterial cell wall, its biosynthesis and recycling. The research team studies every aspect of the process from complex structures for the polymeric entity to the reactions of the various enzymes that are involved with it.  As an off-shoot of these studies, scientists explore discoveries of antibiotics that interfere with the cell-wall processes.

Research Focus

  • Biochemistry

    At the EIGH, our researchers use biochemistry - or the study of chemical substances and their vital role within living organisms - to combat various global health challenges, such as antibiotic resistance and counterfeit drugs.

  • Computational Science

    Computational science is a multidisciplinary field that utilizes advanced computing to understand and solve complex problems. Researchers at the EIGH develop computational models, hardware, software, data management, and more to tackle a variety of global health concerns.

  • Infectious Diseases

    At the EIGH, our researchers work to combat a number of various illnesses, including infectious diseases caused by organisms like bacteria, viruses, fungi, and parasites. These diseases can also be spread from one person to another and may be transmitted from animals to humans. 

  • Molecular Biology and Microbiology

    Researchers at the EIGH use microbiology, which encompasses the study of an entire microorganism, and molecular biology, or the interactivity between molecules within a cell of an organism, to better understand disease and improve global health. 

Who’s Involved

EIGH Faculty

Global Partners

  • Consejo superior de investigaciones científicas (CSIC), Spain

  • National University, Seoul, South Korea

  • Northwest University, China

  • Université catholique de Louvain, Belgium

University of Notre Dame Partnerships

  • Department of Chemistry and Biochemistry

Additional Information

Publications

Byun, B., Mahasenan, K. V., Dik, D. A., Marous, D. R., Speri, E., Kumarasiri, M., Fisher, J. F., Hermoso, J. A., & Mobashery, S. Mechanism of the Escherichia coli MltE Lytic Transglycosylase, the Cell-Wall-Penetrating Enzyme for Type VI Secretion System Assembly.

Lee, M., Batuecas, M. T., Tomoshige, S., Domínguez-Gil, T., Mahasenan, K. V., Dik, D. A., Hesek, D., Millán, C., Usón, I., Lastochkin, E., Hermoso, J. A., & Mobashery, S. Exolytic and Endolytic Turnover of Peptidoglycan by Lytic Transglycosylase Slt of Pseudomonas aeruginosa.

Bernardo-Garcia, N., Mahasenan, K., Batuecas, M., Lee, M., Hesek, D., Petráčková, D., Doubravová, L., Branny, P., Mobashery, S., & Hermoso, J. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.

Meisel, J., Fisher, J., Chang, M., & Mobashery, S. Allosteric Inhibition of Bacterial Targets: an Opportunity for Discovery of Novel Antibacterial Classes. 

Kim, C., Hesek, D., Lee, M., & Mobashery, S. Potentiation of the Activity of β-Lactam Antibiotics by Farnesol and Its Derivatives. 

Tomoshige, S., Dik, D., Akabane-Nakata, M., Madukoma, C., Fisher, J., Shrout, J., & Mobashery, S. Total Syntheses of Bulgecins A, B and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics.

Dik, D., Fisher, J., & Mobashery, S. Cell-Wall Recycling of the Gram-negative Bacteria and the Nexus to Antibiotic Resistance.

Nguyen, T., Ding, D., Wolter, W., Champion, M.,  Hesek, D., Lee, M., Perez, R., Schroeder, V., Suckow, M., Mobashery, S., & Chang, M. Expression of Active Matrix Metalloproteinase-9 As a Likely Contributor to the Clinical Failure of Aclerastide in Treatment of Diabetic Foot Ulcers. 

Chen, S., Chen, Z., Cui, J., McCrary, M., Song, H., Chen, S., Chen, Z., Cui, J., McCrary, M., Song, H., Mobashery, S., Chang, M., & Gu, Z. Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice. 

Ceballos, S., Kim, C., Ding, D., Mobashery, S., Chang, M., & Torres, C.  Activities of Oxadiazole Antibacterials Against Staphylococcus aureus and Other Gram-Positive Bacteria. 

Mahasenan, K., Ding, D., Gao, M., Nguyen, T., Suckow, M., Schroeder, V., Wolter, W., Chang, M., & Mobashery, S. In Search of Selectivity in Inhibition of ADAM10. 

Fisher, J., & Mobashery, S. A Positive Positive to Negative (A News & Views).

Nguyen, T., Ding, D., Wolter, W., Pérez, R., Champion, M., Mahasenan, K., Hesek, D., Lee, M., Schroeder, V., Jones, J., Lastochkin, E., Rose, M., Peterson, C., Suckow, M., Mobashery, S., & Chang, M. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor that Accelerates Healing. 

Dik, D., Batuecas, M., Lee, M., Mahasenan, K., Marous, D., Lastochkin, E., Fisher, J., Hermoso, J., & Mobashery, S. Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

Speri, E., Fishovitz, J., & Mobashery, S. Structure-Activity Relationship of the Cinnamamide Family of Antibiotic Potentiators for Methicillin-Resistant Staphylococcus aureus (MRSA).

Raz, L., Yang, Y., Thompson, J., Hobson, S., Pesko, J., Mobashery, S., Chang, M., & Rosenberg, G. MMP-9 Inhibition Impairs Learning in Spontaneously Hypertensive Rats.

Dik, D., Madukoma, C., Tomoshige, S., Kim, C., Lastochkin, E., Boggess, W., Fisher, J., Shrout, J., & Mobashery, S., Slt, MltD and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of b-Lactam Antibiotics. 

Janardhanan, J., Bouley, R., Martínez-Caballero, S., Peng, Z., Batuecas-Mordillo, M., Meisel, J., Ding, D., Schroeder, V., Wolter, W., Mahasenan, K., Hermoso, J., Mobashery, S., & Chang, M. The Quinazolinone Allosteric Inhibitor of PBP2a Synergizes with Piperacillin and Tazobactam Against Methicillin-Resistant Staphylococcus aureus, Antimicrob.