The human gut microbiome, immunity, and infectious disease
This project addresses a major emerging topic in global infectious disease, viz. determining the role that gut microbial communities may play in infectious disease transmission and ultimately in their control. We are combining field surveys with molecular epidemiology, immunological assays, bioinformatics, and mathematical modelling to characterize the gut microbiomes related to infection with malaria and soil-transmitted helminths and pathways that link microbiota variations to disease outcomes. The information arising from these studies will also be analyzed against data on diets and other socio-economic factors, so that predictive models of these interactions can be developed to better understand the ecology of these diseases, and to examine the potential of using probiotic-based therapeutic options for their control.
Computational science is a multidisciplinary field that utilizes advanced computing to understand and solve complex problems. Researchers at the EIGH develop computational models, hardware, software, data management, and more to tackle a variety of global health concerns.
At the EIGH, our researchers use epidemiology to understand the distribution and determinants of the health and disease conditions in specific populations, and to identify risk factors for certain diseases. This allows them to develop, implement, and measure the impact of targeted, preventative healthcare methods.
Genetics and Genomics
One way to study certain diseases is through genetics - the study of heredity and the variation of individual inherited genes in an organism. At the EIGH, this means studying how organisms can inherit and spread certain diseases. Additionally, by analyzing the entire structure, function, and evolution of an organism's genes, researchers may identify ways to prevent a disease from genetically passing disease traits.
At the EIGH, our researchers work to combat a number of various illnesses, including infectious diseases caused by organisms like bacteria, viruses, fungi, and parasites. These diseases can also be spread from one person to another and may be transmitted from animals to humans.
Molecular Biology and Microbiology
Researchers at the EIGH use microbiology, which encompasses the study of an entire microorganism, and molecular biology, or the interactivity between molecules within a cell of an organism, to better understand disease and improve global health.
NOTRE DAME PARTNERSHIPS
- Genomics & Bioinformatics Core Facility
- Department of Biological Sciences
Huwe, T., Prusty, B., Ray, A., Lee, S., Ravindran, B., and Michael, E. Interactions between Parasitic Infections and the Human Gut Microbiome in Odisha, India.